Schedule

Wednesday Workshops

The schedule for the Wednesday workshops is described in the course overview.

NONMEM Workshop

Thursday (full day): Statistical basis of population modeling. Advanced NONMEM control files and data structures. Limited modeling with Excel. Creating a NONMEM data set with R. By Thursday afternoon, users will have NONMEM and R running on their laptop computers. Users will spend the last 2 hours working with the provided examples or their own data sets. The examples cover the entire curriculum, ranging from simple pharmacokinetic analysis to integrated PK/PD models of indirect drug effects and target controlled drug administration. The instructors will work with individual students, providing personal guidance through issues encountered with the examples or modeling of their own data.

Friday (full day): Model building with NONMEM, including advanced pharmacodynamic models, variance models, covariate models, simulation, and model diagnostics. Introduction to Windows and Unix scripting, part 11 compliance, and traceability. The afternoon is devoted to users working with the examples or modeling their own data, again with the instructors providing personal guidance.

Saturday (full day): Building pharmacodynamic models (including modeling binary and ordered categorical data), model validation, simulation, and power analysis. The afternoon will be devoted to users working with the examples or their own data.

Sunday (morning): Sunday will be conducted as a roundtable discussion. The instructors and attendees will talk through data analysis issues brought up during the workshop. In prior courses, both the instructors and the attendees have contributed ideas about how to tackle difficult problems. Although Sunday is unstructured, feedback from prior courses suggests that this unstructured morning is the most valuable part of the workshop for the participants.