Curriculum

Pharmacokinetics: 1, 2, and 3 compartment mammillary models, including bolus, infusion, absorption, deconvolution analysis of controlled release formulations, and target controlled drug delivery.

Pharmacodynamics: sigmoidal models of drug effect, modeling binary response/no response data, hysteresis, combined PK/PD modeling, modeling indirect drug effects, nonparametric models.

NONMEM: Setting up data files, control files, running NONMEM, interpretation of NONMEM output.

Model Building: Exploring covariate structures, model diagnostics.

Special: Modeling with Excel, data input/output and graphics with R, simulation, power analysis, interoccasion variability, scripting in DOS and UNIX to organize NONMEM analyses and provide 21 CFR 11 compliance.

Course attendees must bring their own laptop computers. We recommend that users have Excel installed.

Course attendees are encouraged to bring their own data to use in place of the supplied examples, if they have such data sets available to them. About a third of attendees typically bring their own data to analyze with NONMEM.�

NONMEM need not be installed on the laptop prior to attending the course. However, all attendees must have a NONMEM license, either personally or through their employer, before attending the course. NONMEM licenses can be obtained from Globomax corporation, Phone: 1 410 782-2703, FAX: 1 410 712-0737